BDBM669877 (S)-4-(6-(3,4-dihydropyran-6-yl)-1H-pyrrol[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 109

SMILES FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)C1=CCCCO1

InChI Key InChIKey=YBLOCRXWYOGVKP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 669877   

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Gt Apeiron Therapeutics

US Patent
LigandPNGBDBM669877(US20240132489, Compound 109 | (S)-4-(6-(3,4-dihydr...)
Affinity DataIC50: 5.62nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Gt Apeiron Therapeutics

US Patent
LigandPNGBDBM669877(US20240132489, Compound 109 | (S)-4-(6-(3,4-dihydr...)
Affinity DataIC50: 2.15E+3nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
Go to US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Gt Apeiron Therapeutics

US Patent
LigandPNGBDBM669877(US20240132489, Compound 109 | (S)-4-(6-(3,4-dihydr...)
Affinity DataIC50: 2.87E+3nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
Go to US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Gt Apeiron Therapeutics

US Patent
LigandPNGBDBM669877(US20240132489, Compound 109 | (S)-4-(6-(3,4-dihydr...)
Affinity DataIC50: 1.00E+3nMAssay Description:The test was performed in a U-shaped bottom 384-well plate (coming, 4512 #), and the reaction temperature was 27° C. CDK7/CyclinH was diluted in a te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2024
Entry Details
Go to US Patent