BDBM669480 US11964990, Example 22::US20250066388, Example 22

SMILES COCCN1CCC(F)(COc2ncc(cc2Cl)S(=O)(=O)NC(=O)c2ccc(cc2N2CCCOc3nc4[nH]ccc4cc23)N2CCN3CC4=C(CC(C)(C)C[C@H]4OCCCOC[C@@H]3C2)c2ccc(Cl)cc2)CC1

InChI Key InChIKey=FHPRBAXZKKBMJA-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 669480   

TargetApoptosis regulator Bcl-2(Human)
Abbvie

US Patent
LigandPNGBDBM669480(US11964990, Example 22 | US20250066388, Example 22)
Affinity DataKi:  0.339nMAssay Description:[Bcl-2 protein or Bcl-xL protein], [Probe], [Antibody],Protein Probe nM nM Antibody nMGST- F-Bak 1 100 Tb-anti- 1Bcl- Acetyl-(SEQ GST 2 ID NO: 3)-NH2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2024
Entry Details
Go to US Patent

TargetApoptosis regulator Bcl-2(Human)
Abbvie

US Patent
LigandPNGBDBM669480(US11964990, Example 22 | US20250066388, Example 22)
Affinity DataKi:  0.339nMAssay Description:The samples were then mixed on a shaker for 1 minute and equilibrated for an additional 3 hours at room temperature. For each assay plate, a probe/an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
Abbvie

US Patent
LigandPNGBDBM669480(US11964990, Example 22 | US20250066388, Example 22)
Affinity DataKi:  14.7nMAssay Description:[Bcl-2 protein or Bcl-xL protein], [Probe], [Antibody],Protein Probe nM nM Antibody nMGST- F-Bak 1 100 Tb-anti- 1Bcl- Acetyl-(SEQ GST 2 ID NO: 3)-NH2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2024
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
Abbvie

US Patent
LigandPNGBDBM669480(US11964990, Example 22 | US20250066388, Example 22)
Affinity DataKi:  14.7nMAssay Description:The samples were then mixed on a shaker for 1 minute and equilibrated for an additional 3 hours at room temperature. For each assay plate, a probe/an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent