BDBM669465 US11964990, Example 7::US20250066388, Example 7

SMILES CC1(C)C[C@H]2OCCCOC[C@@H]3CN(CCN3CC2=C(C1)c1ccc(Cl)cc1)c1ccc(C(=O)NS(=O)(=O)c2cnc(OCC3(F)CCOCC3)c(Cl)c2)c(c1)N1CCCOc2nc3[nH]ccc3cc12

InChI Key InChIKey=GIYLCQVENWAWHE-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 669465   

TargetApoptosis regulator Bcl-2(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM669465(US11964990, Example 7 | US20250066388, Example 7)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of human Bcl-2 expressed in Escherichia coli BL21(DE3) T1R cells preincubated under shaking condition for 1 min and measured after 3 hrs b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM669465(US11964990, Example 7 | US20250066388, Example 7)
Affinity DataKi:  0.0500nMAssay Description:[Bcl-2 protein or Bcl-xL protein], [Probe], [Antibody],Protein Probe nM nM Antibody nMGST- F-Bak 1 100 Tb-anti- 1Bcl- Acetyl-(SEQ GST 2 ID NO: 3)-NH2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2024
Entry Details
Go to US Patent

TargetApoptosis regulator Bcl-2(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM669465(US11964990, Example 7 | US20250066388, Example 7)
Affinity DataKi:  0.0500nMAssay Description:The samples were then mixed on a shaker for 1 minute and equilibrated for an additional 3 hours at room temperature. For each assay plate, a probe/an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM669465(US11964990, Example 7 | US20250066388, Example 7)
Affinity DataKi: >661nMAssay Description:Inhibition of human Bcl-xL expressed in Escherichia coli BL21(DE3) T1R cells preincubated under shaking condition for 1 min and measured after 3 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM669465(US11964990, Example 7 | US20250066388, Example 7)
Affinity DataKi: >661nMAssay Description:[Bcl-2 protein or Bcl-xL protein], [Probe], [Antibody],Protein Probe nM nM Antibody nMGST- F-Bak 1 100 Tb-anti- 1Bcl- Acetyl-(SEQ GST 2 ID NO: 3)-NH2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2024
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM669465(US11964990, Example 7 | US20250066388, Example 7)
Affinity DataKi: >661nMAssay Description:The samples were then mixed on a shaker for 1 minute and equilibrated for an additional 3 hours at room temperature. For each assay plate, a probe/an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2025
Entry Details
Go to US Patent