BDBM6683 aminoimidazo[1,2-a]pyridine deriv. 18::{2-amino-6-[(2,6-difluorophenyl)carbonyl]imidazo[1,2-a]pyridin-3-yl}(2,6-difluorophenyl)methanethione

SMILES Nc1nc2ccc(cn2c1C(=S)c1c(F)cccc1F)C(=O)c1c(F)cccc1F

InChI Key InChIKey=HARCNHPDYDKMHE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 6683   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Avenida De La Industria

LigandPNGBDBM6683({2-amino-6-[(2,6-difluorophenyl)carbonyl]imidazo[1...)
Affinity DataIC50: 26nMpH: 7.0 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Avenida De La Industria

LigandPNGBDBM6683({2-amino-6-[(2,6-difluorophenyl)carbonyl]imidazo[1...)
Affinity DataIC50: 105nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Avenida De La Industria

LigandPNGBDBM6683({2-amino-6-[(2,6-difluorophenyl)carbonyl]imidazo[1...)
Affinity DataIC50: 786nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Avenida De La Industria

LigandPNGBDBM6683({2-amino-6-[(2,6-difluorophenyl)carbonyl]imidazo[1...)
Affinity DataIC50: 786nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) using pRb (246 to 257 residues) as substrate in presence of [gamma33P]-ATP by topcount scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Avenida De La Industria

LigandPNGBDBM6683({2-amino-6-[(2,6-difluorophenyl)carbonyl]imidazo[1...)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant CDK2/Cyclin E (unknown origin) expressed in baculovirus infected Sf9 insect cells using pRb (246 to 257 residues) as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Avenida De La Industria

LigandPNGBDBM6683({2-amino-6-[(2,6-difluorophenyl)carbonyl]imidazo[1...)
Affinity DataIC50: 105nMAssay Description:Inhibition of recombinant human CDK1/cyclin B expressed in baculovirus infected Sf9 insect cells using histone H1 as substrate in presence of [gamma3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed