BDBM668209 US20240124450, Example 48

SMILES COc1cc(cc(OCC2(N)CCCC2)c1C#N)-c1cnc2ccc(N(C)C)c(C#N)n12

InChI Key InChIKey=YATIMLFNGFQTCA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 668209   

TargetSerine/threonine-protein kinase SIK1(Human)
Pfizer

US Patent
LigandPNGBDBM668209(US20240124450, Example 48)
Affinity DataIC50: 0.400nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Pfizer

US Patent
LigandPNGBDBM668209(US20240124450, Example 48)
Affinity DataIC50: 0.700nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668209(US20240124450, Example 48)
Affinity DataIC50: 1.70nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
Go to US Patent