BDBM668188 US20240124450, Example 31

SMILES COCC1CCC[C@@](N)(COc2cc(cc(SC)c2C#N)-c2cnc3ccccn23)C1

InChI Key InChIKey=CAJPKOHOPAWXRV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 668188   

TargetSerine/threonine-protein kinase SIK1(Human)
Pfizer

US Patent
LigandPNGBDBM668188(US20240124450, Example 31)
Affinity DataIC50: 0.700nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Pfizer

US Patent
LigandPNGBDBM668188(US20240124450, Example 31)
Affinity DataIC50: 1.60nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668188(US20240124450, Example 31)
Affinity DataIC50: 4.80nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
Go to US Patent