BDBM668170 US20240124450, Example 20A::US20240124450, Example 20B

SMILES COc1cc(cc(OC[C@]2(N)CCCC22CCCC2)c1C#N)-c1cnc2cccc(OC)n12

InChI Key InChIKey=IVKGWWZSELOWKX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 668170   

TargetSerine/threonine-protein kinase SIK1(Human)
Pfizer

US Patent
LigandPNGBDBM668170(US20240124450, Example 20A | US20240124450, Exampl...)
Affinity DataIC50: 51.8nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Pfizer

US Patent
LigandPNGBDBM668170(US20240124450, Example 20A | US20240124450, Exampl...)
Affinity DataIC50: 49.6nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668170(US20240124450, Example 20A | US20240124450, Exampl...)
Affinity DataIC50: 218nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Pfizer

US Patent
LigandPNGBDBM668170(US20240124450, Example 20A | US20240124450, Exampl...)
Affinity DataIC50: 0.5nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Pfizer

US Patent
LigandPNGBDBM668170(US20240124450, Example 20A | US20240124450, Exampl...)
Affinity DataIC50: 0.800nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Pfizer

US Patent
LigandPNGBDBM668170(US20240124450, Example 20A | US20240124450, Exampl...)
Affinity DataIC50: 3.90nMAssay Description:Salt Induced Kinase (SIK) activity is determined by measuring the effect of a test agent on the activity of the appropriate SIK enzyme to phosphoryla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2024
Entry Details
Go to US Patent