BDBM667825 US11958865, Example 20

SMILES Cc1c2Nc3ncc4c(Cl)nn(CCCOc2nn1-c1cccnc1OC(F)(F)F)c4n3

InChI Key InChIKey=HHNYAGQNGCJGQR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 667825   

Targetlrrk2 wt adpglo(Human)
H. Lundbeck

US Patent
LigandPNGBDBM667825(US11958865, Example 20)
Affinity DataIC50: 0.480nMAssay Description:In the assay, 0.5 nM LRRK2 WT kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 2 μM) for 30 minutes befo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

LigandPNGBDBM667825(US11958865, Example 20)
Affinity DataIC50: 1.10nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Targetlrrk2 wt adpglo(Human)
H. Lundbeck

US Patent
LigandPNGBDBM667825(US11958865, Example 20)
Affinity DataIC50: 3.40nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent