BDBM667815 US11958865, Example 10::US11958865, Example 30

SMILES Cc1c2Nc3ncc4c(Cl)nn(CCCOc2nn1-c1cc(F)cnc1C)c4n3

InChI Key InChIKey=BLCVBTGWVASKGQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 667815   

Targetlrrk2 wt adpglo(Human)
H. Lundbeck

US Patent
LigandPNGBDBM667815(US11958865, Example 30 | US11958865, Example 10)
Affinity DataIC50: 1nMAssay Description:In the assay, 0.5 nM LRRK2 WT kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 2 μM) for 30 minutes befo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Targetlrrk2 wt adpglo(Human)
H. Lundbeck

US Patent
LigandPNGBDBM667815(US11958865, Example 30 | US11958865, Example 10)
Affinity DataIC50: 1.40nMAssay Description:In the assay, 0.5 nM LRRK2 WT kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 2 μM) for 30 minutes befo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

LigandPNGBDBM667815(US11958865, Example 30 | US11958865, Example 10)
Affinity DataIC50: 2.70nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

LigandPNGBDBM667815(US11958865, Example 30 | US11958865, Example 10)
Affinity DataIC50: 7.70nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Targetlrrk2 wt adpglo(Human)
H. Lundbeck

US Patent
LigandPNGBDBM667815(US11958865, Example 30 | US11958865, Example 10)
Affinity DataIC50: 8.80nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Targetlrrk2 wt adpglo(Human)
H. Lundbeck

US Patent
LigandPNGBDBM667815(US11958865, Example 30 | US11958865, Example 10)
Affinity DataIC50: 16nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent