BDBM667811 US11958865, Example 7

SMILES COc1nccc(C)c1-n1nc2OCCCn3nc(Cl)c4cnc(Nc2c1C)nc34

InChI Key InChIKey=ZDIQRRLORNYRLZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 667811   

LigandPNGBDBM667811(US11958865, Example 7)
Affinity DataIC50: 2.30nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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LigandPNGBDBM667811(US11958865, Example 7)
Affinity DataIC50: 6.90nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

LigandPNGBDBM667811(US11958865, Example 7)
Affinity DataIC50: 0.780nMAssay Description:In the assay, 0.5 nM LRRK2 WT kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 2 μM) for 30 minutes befo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent