BDBM667810 US11958865, Example 23::US11958865, Example 29::US11958865, Example 6

SMILES COc1ncc(F)cc1-n1nc2OCCCn3nc(Cl)c4cnc(Nc2c1C)nc34

InChI Key InChIKey=DZVQZVKXUSRDDF-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 667810   

LigandPNGBDBM667810(US11958865, Example 23 | US11958865, Example 29 | ...)
Affinity DataIC50: 0.200nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
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LigandPNGBDBM667810(US11958865, Example 23 | US11958865, Example 29 | ...)
Affinity DataIC50: 0.530nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

LigandPNGBDBM667810(US11958865, Example 23 | US11958865, Example 29 | ...)
Affinity DataIC50: 0.400nMAssay Description:In the assay, 0.5 nM LRRK2 WT kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 2 μM) for 30 minutes befo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

LigandPNGBDBM667810(US11958865, Example 23 | US11958865, Example 29 | ...)
Affinity DataIC50: 0.320nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

LigandPNGBDBM667810(US11958865, Example 23 | US11958865, Example 29 | ...)
Affinity DataIC50: 0.610nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

LigandPNGBDBM667810(US11958865, Example 23 | US11958865, Example 29 | ...)
Affinity DataIC50: 0.340nMAssay Description:In the assay, 0.5 nM LRRK2 WT kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 2 μM) for 30 minutes befo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

LigandPNGBDBM667810(US11958865, Example 23 | US11958865, Example 29 | ...)
Affinity DataIC50: 0.790nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

LigandPNGBDBM667810(US11958865, Example 23 | US11958865, Example 29 | ...)
Affinity DataIC50: 2.40nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent

LigandPNGBDBM667810(US11958865, Example 23 | US11958865, Example 29 | ...)
Affinity DataIC50: 0.530nMAssay Description:In the assay, 0.5 nM LRRK2 WT kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 2 μM) for 30 minutes befo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
Go to US Patent