BDBM667807 US11958865, Example 26::US11958865, Example 3
SMILES Cc1c2Nc3ncc4c(Cl)nn(CCCOc2nn1-c1cccnc1C)c4n3
InChI Key InChIKey=CYAZJNIKVWTGJH-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 667807
Affinity DataIC50: 0.960nMAssay Description:In the assay, 0.5 nM LRRK2 WT kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 2 μM) for 30 minutes befo...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:In the assay, 0.5 nM LRRK2 WT kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 2 μM) for 30 minutes befo...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)(Human)
H. Lundbeck
US Patent
H. Lundbeck
US Patent
Affinity DataIC50: 1.70nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S)(Human)
H. Lundbeck
US Patent
H. Lundbeck
US Patent
Affinity DataIC50: 1.90nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.60nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair