BDBM667805 US11958865, Example 1::US11958865, Example 24::US11958865, Example 28

SMILES COc1ncccc1-n1nc2OCCCn3nc(Cl)c4cnc(Nc2c1C)nc34

InChI Key InChIKey=LDFXRLNXLQBRHK-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 667805   

LigandPNGBDBM667805(US11958865, Example 24 | US11958865, Example 28 | ...)
Affinity DataIC50: 0.230nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

LigandPNGBDBM667805(US11958865, Example 24 | US11958865, Example 28 | ...)
Affinity DataIC50: 0.350nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

LigandPNGBDBM667805(US11958865, Example 24 | US11958865, Example 28 | ...)
Affinity DataIC50: 0.450nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Targetlrrk2 wt adpglo(Human)
H. Lundbeck

US Patent
LigandPNGBDBM667805(US11958865, Example 24 | US11958865, Example 28 | ...)
Affinity DataIC50: 0.460nMAssay Description:In the assay, 0.5 nM LRRK2 WT kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 2 μM) for 30 minutes befo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Targetlrrk2 wt adpglo(Human)
H. Lundbeck

US Patent
LigandPNGBDBM667805(US11958865, Example 24 | US11958865, Example 28 | ...)
Affinity DataIC50: 0.490nMAssay Description:In the assay, 0.5 nM LRRK2 WT kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 2 μM) for 30 minutes befo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Targetlrrk2 wt adpglo(Human)
H. Lundbeck

US Patent
LigandPNGBDBM667805(US11958865, Example 24 | US11958865, Example 28 | ...)
Affinity DataIC50: 0.630nMAssay Description:In the assay, 0.5 nM LRRK2 WT kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 2 μM) for 30 minutes befo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Targetlrrk2 wt adpglo(Human)
H. Lundbeck

US Patent
LigandPNGBDBM667805(US11958865, Example 24 | US11958865, Example 28 | ...)
Affinity DataIC50: 0.760nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Targetlrrk2 wt adpglo(Human)
H. Lundbeck

US Patent
LigandPNGBDBM667805(US11958865, Example 24 | US11958865, Example 28 | ...)
Affinity DataIC50: 0.950nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Targetlrrk2 wt adpglo(Human)
H. Lundbeck

US Patent
LigandPNGBDBM667805(US11958865, Example 24 | US11958865, Example 28 | ...)
Affinity DataIC50: 1.10nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase in kinase reaction buffer was incubated with the test compound (typically at 0 to 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent