BDBM667581 N-(3,6-dimethoxy-9H- thioxanthen-9-yl)-2-oxo-6- (trifluoromethyl)-1,2- dihydropyridine-3- carboxamide::US11957687, Compound 241

SMILES COc1ccc2C(NC(=O)c3ccc([nH]c3=O)C(F)(F)F)c3ccc(OC)cc3Sc2c1

InChI Key InChIKey=VCTJUBHTQXOBCV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 667581   

Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667581(N-(3,6-dimethoxy-9H- thioxanthen-9-yl)-2-oxo-6- (t...)
Affinity DataIC50: 30nMAssay Description:Compounds of the disclosure were screened for their ability to block HSD17B13 function using an enzymatic blocking assay. HSD17B13 activity was quant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667581(N-(3,6-dimethoxy-9H- thioxanthen-9-yl)-2-oxo-6- (t...)
Affinity DataIC50: 1.58E+4nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B1 function, an enzymatic blocking assay was performed. For the assay, HSD17B1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

TargetPeroxisomal multifunctional enzyme type 2(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667581(N-(3,6-dimethoxy-9H- thioxanthen-9-yl)-2-oxo-6- (t...)
Affinity DataIC50: 1.00E+5nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B2 function, an enzymatic blocking assay was performed. For the assay, HSD17B2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent