BDBM667549 N-(3,6-dimethyl-9H- xanthen-9-yl)-2-oxo-5- ((tetrahydro-2H-pyran-4- yl)oxy)-6-(trifluoromethyl)- 1,2-dihydropyridine-3- carboxamide::US11957687, Compound 260

SMILES Cc1ccc2C(NC(=O)c3cc(OC4CCOCC4)c([nH]c3=O)C(F)(F)F)c3ccc(C)cc3Oc2c1

InChI Key InChIKey=PXCRSWUWOIBRAJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 667549   

Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667549(N-(3,6-dimethyl-9H- xanthen-9-yl)-2-oxo-5- ((tetra...)
Affinity DataIC50: 20nMAssay Description:Compounds of the disclosure were screened for their ability to block HSD17B13 function using an enzymatic blocking assay. HSD17B13 activity was quant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667549(N-(3,6-dimethyl-9H- xanthen-9-yl)-2-oxo-5- ((tetra...)
Affinity DataIC50: 1.11E+4nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B1 function, an enzymatic blocking assay was performed. For the assay, HSD17B1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

TargetPeroxisomal multifunctional enzyme type 2(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667549(N-(3,6-dimethyl-9H- xanthen-9-yl)-2-oxo-5- ((tetra...)
Affinity DataIC50: 3.21E+4nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B2 function, an enzymatic blocking assay was performed. For the assay, HSD17B2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent