BDBM667198 N-(3,6-dimethyl-9H- xanthen-9-yl)-5-ethyl-2-oxo- 6-(trifluoromethyl)-1,2- dihydropyridine-3- carboxamide::US11957687, Compound 176

SMILES CCc1cc(C(=O)NC2c3ccc(C)cc3Oc3cc(C)ccc23)c(=O)[nH]c1C(F)(F)F

InChI Key InChIKey=BVHYOYYFUGIDPA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 667198   

Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667198(US11957687, Compound 176 | N-(3,6-dimethyl-9H- xan...)
Affinity DataIC50: 20nMAssay Description:Compounds of the disclosure were screened for their ability to block HSD17B13 function using an enzymatic blocking assay. HSD17B13 activity was quant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667198(US11957687, Compound 176 | N-(3,6-dimethyl-9H- xan...)
Affinity DataIC50: 6.43E+3nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B1 function, an enzymatic blocking assay was performed. For the assay, HSD17B1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

TargetPeroxisomal multifunctional enzyme type 2(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667198(US11957687, Compound 176 | N-(3,6-dimethyl-9H- xan...)
Affinity DataIC50: 2.83E+4nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B2 function, an enzymatic blocking assay was performed. For the assay, HSD17B2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent