BDBM667188 5-(cyclohex-1-en-1-yl)-N- (3,6-dimethyl-9H-xanthen- 9-yl)-2-oxo-6- (trifluoromethyl)-1,2- dihydropyridine-3- carboxamide::US11957687, Compound 183::US11957687, Compound 505

SMILES Cc1ccc2C(NC(=O)c3cc(C4=CCCCC4)c([nH]c3=O)C(F)(F)F)c3ccc(C)cc3Oc2c1

InChI Key InChIKey=RUVKDOYXTSRZRL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 667188   

Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667188(US11957687, Compound 183 | 5-(cyclohex-1-en-1-yl)-...)
Affinity DataIC50: 30nMAssay Description:Compounds of the disclosure were screened for their ability to block HSD17B13 function using an enzymatic blocking assay. HSD17B13 activity was quant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Target17-beta-hydroxysteroid dehydrogenase 13(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667188(US11957687, Compound 183 | 5-(cyclohex-1-en-1-yl)-...)
Affinity DataIC50: 80nMAssay Description:Compounds of the disclosure were screened for their ability to block HSD17B13 function using an enzymatic blocking assay. HSD17B13 activity was quant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667188(US11957687, Compound 183 | 5-(cyclohex-1-en-1-yl)-...)
Affinity DataIC50: 4.55E+3nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B1 function, an enzymatic blocking assay was performed. For the assay, HSD17B1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

TargetPeroxisomal multifunctional enzyme type 2(Human)
Regeneron Pharmaceuticals

US Patent
LigandPNGBDBM667188(US11957687, Compound 183 | 5-(cyclohex-1-en-1-yl)-...)
Affinity DataIC50: 9.61E+3nMAssay Description:To screen compounds of the disclosure for their ability to block HSD17B2 function, an enzymatic blocking assay was performed. For the assay, HSD17B2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent