BDBM664705 US20240115577, Compound 6::methyl (R)-7-(3-amino-4-(2,4,5- trifluorophenyl)butanoyl)-3-(trifluoromethyl)- 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1- carboxylate (Retagliptin)

SMILES COC(=O)c1nc(n2CCN(Cc12)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F)C(F)(F)F

InChI Key InChIKey=WIIAMRXFUJLYEF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 664705   

TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM664705(methyl (R)-7-(3-amino-4-(2,4,5- trifluorophenyl)bu...)
Affinity DataIC50: 12nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM664705(methyl (R)-7-(3-amino-4-(2,4,5- trifluorophenyl)bu...)
Affinity DataIC50: 0.600nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
Go to US Patent