BDBM663852 US20240109915, Example 34

SMILES Cc1cc(C(=O)N2CCC3(CC2)Cc2sc(nc2C(=O)C3)C(C)(C)C)c2[nH]ncc2c1Cl

InChI Key InChIKey=DKLGSKYWMKRRNF-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 663852   

TargetAcetyl-CoA carboxylase 1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL

LigandBDBM663852(US20240109915, Example 34)Copy SMILESCopy InChI

Affinity DataIC50: 1.30nMAssay Description:Inhibition of full length human recombinant ACC1 expressed in baculovirus infected Sf9 cells incubated for 18 hrs in presence of ATP by envision fluo...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/16/2024
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetActivating signal cointegrator 1 complex subunit 1(Human)
Pfizer

US Patent

LigandBDBM663852(US20240109915, Example 34)Copy SMILESCopy InChI

Affinity DataIC50: 1.30nMAssay Description:The ACC inhibitory activity of the compounds of the present invention was demonstrated by methods based on standard procedures. The direct inhibition...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/20/2024
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL