BDBM663524 5-(6-((1S,6R,7R)-7-(aminomethyl)-7-(2- fluorophenyl)-3-azabicyclo[4.1.0]heptan-3-yl)-1H- pyrazolo[3,4-b]pyrazin-3-yl)-4-chloro-3,3-difluoro-1- methylindolin-2-one::US20240109900, Example 362

SMILES CN1C(=O)C(F)(F)c2c1ccc(-c1n[nH]c3nc(cnc13)N1CC[C@@H]3[C@H](C1)[C@@]3(CN)c1ccccc1F)c2Cl

InChI Key InChIKey=FQLOFIGMLZUBOS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 663524   

LigandPNGBDBM663524(5-(6-((1S,6R,7R)-7-(aminomethyl)-7-(2- fluoropheny...)
Affinity DataIC50: 500nMAssay Description:Assay volume of 20 μL/well was assembled in 384 well black polystyrene low-binding microplates (Greiner), using the following buffer: 60 mM HEPE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent