BDBM663064 US20240109893, Example 854

SMILES Fc1c(ncc2c(nc(OCC3(CN4CCCC4)CC3)nc12)N1CCN([C@@H](CC#N)C1)C(=O)C=C)-c1cccc2cccc(Cl)c12

InChI Key InChIKey=WAAAKAKUJXFVAM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 663064   

TargetGTPase KRas [G12C](Human)
Shanghai Kechow Pharma

US Patent
LigandPNGBDBM663064(US20240109893, Example 854)
Affinity DataIC50: 0.590nMAssay Description:1. Serially 4×-diluted compounds (10 concentration points in total) were separately premixed with KRAS G12C-GDP (ICE, Kras 20191018) in a reaction bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
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