BDBM663053 US20240109893, Example 3

SMILES FC(=C)C(=O)N1CCN(C[C@@H]1CC#N)c1nc(OCC23CCCN2CCC3)nc2c(F)c(ncc12)-c1cccc2CCCCc12

InChI Key InChIKey=QLLKLIRJLIOUQB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 663053   

TargetGTPase KRas [G12C](Human)
Shanghai Kechow Pharma

US Patent
LigandPNGBDBM663053(US20240109893, Example 3)
Affinity DataIC50: 13.8nMAssay Description:1. Serially 4×-diluted compounds (10 concentration points in total) were separately premixed with KRAS G12C-GDP (ICE, Kras 20191018) in a reaction bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent