BDBM663052 US20240109893, Example 2

SMILES Fc1c(ncc2c(nc(OCC34CCCN3CCC4)nc12)N1CCN([C@@H](CC#N)C1)C(=O)C=C)-c1cccc2CCCCc12

InChI Key InChIKey=ILSZPBVJHYHUAQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 663052   

TargetGTPase KRas [G12C](Human)
Shanghai Kechow Pharma

US Patent
LigandPNGBDBM663052(US20240109893, Example 2)
Affinity DataIC50: 10.6nMAssay Description:1. Serially 4×-diluted compounds (10 concentration points in total) were separately premixed with KRAS G12C-GDP (ICE, Kras 20191018) in a reaction bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent