BDBM662959 US20240109877, Example 13

SMILES CC(C)[C@H]1CN(CCc2ccc(cc2)N2CCC(=O)NC2=O)CCN1c1ccc(Nc2cc(ncn2)-c2ccc([C@@H](C)NC(=O)c3nc(no3)C(C)(C)C)c(C)c2)nc1

InChI Key InChIKey=FJLQPZAPFKXILN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 662959   

TargetTyrosine-protein kinase BTK(Human)
Abbvie

US Patent
LigandPNGBDBM662959(US20240109877, Example 13)
Affinity DataIC50: 0.140nMAssay Description:Btk kinase activity was measured in vitro using an electrophoretic mobility shift assay (MSA). The ability of Btk to phosphorylate a fluorescent pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
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TargetProtein cereblon(Human)
Abbvie

US Patent
LigandPNGBDBM662959(US20240109877, Example 13)
Affinity DataIC50: 1.00E+4nMAssay Description:Competition Assay: Test compounds in 100% dimethyl sulfoxide were plated onto white, low volume 384 well plates (PerkinElmer Proxiplate 384 plus # 60...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent