BDBM662949 US20240109877, Example 3

SMILES C[C@@H](NC(=O)c1nc(no1)C(C)(C)C)c1ccc(cc1C)-c1cc(Nc2ccc(cn2)N2CCN(CCc3ccc(cc3)N3CCC(=O)NC3=O)CC2)ncn1

InChI Key InChIKey=XTTYHHPEDDXLEH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 662949   

TargetTyrosine-protein kinase BTK(Human)
Abbvie

US Patent
LigandPNGBDBM662949(US20240109877, Example 3)
Affinity DataIC50: 0.0340nMAssay Description:Btk kinase activity was measured in vitro using an electrophoretic mobility shift assay (MSA). The ability of Btk to phosphorylate a fluorescent pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
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TargetProtein cereblon(Human)
Abbvie

US Patent
LigandPNGBDBM662949(US20240109877, Example 3)
Affinity DataIC50: 9.57E+3nMAssay Description:Competition Assay: Test compounds in 100% dimethyl sulfoxide were plated onto white, low volume 384 well plates (PerkinElmer Proxiplate 384 plus # 60...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent