BDBM662766 US20240109865, Example 189.::isopropyl 2-[5-[5-[(1R)-1-(3,5- dimethylpyridazin-4- yl)ethoxy]-1H-indazol-3-yl]-2- pyridyl]-2,8- diazaspiro[3.5]nonane-8- carboxylate

SMILES CC(C)OC(=O)N1CCCC2(CN(C2)c2ccc(cn2)-c2n[nH]c3ccc(O[C@H](C)c4c(C)cnnc4C)cc23)C1

InChI Key InChIKey=LYXNIAMPEBTYHT-UHFFFAOYSA-N

Data  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 662766   

TargetFibroblast growth factor receptor 1(Human)
Tyra Biosciences

US Patent
LigandPNGBDBM662766(US20240109865, Example 189. | isopropyl 2-[5-[5-[(...)
Affinity DataKd:  60nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Tyra Biosciences

US Patent
LigandPNGBDBM662766(US20240109865, Example 189. | isopropyl 2-[5-[5-[(...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Tyra Biosciences

US Patent
LigandPNGBDBM662766(US20240109865, Example 189. | isopropyl 2-[5-[5-[(...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3 [V555M](Human)
Tyra Biosciences

US Patent
LigandPNGBDBM662766(US20240109865, Example 189. | isopropyl 2-[5-[5-[(...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Tyra Biosciences

US Patent
LigandPNGBDBM662766(US20240109865, Example 189. | isopropyl 2-[5-[5-[(...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent