BDBM662581 US20240109865, Example 4.::[4-[5-[5-[(1R)-1- (3,5-dichloro-4- pyridyl)ethoxy]- 1H-indazol-3-yl]- 2-pyridyl]piperazin- 1-yl]-(4- methylpiperazin-1- yl)methanone

SMILES C[C@@H](Oc1ccc2[nH]nc(-c3ccc(nc3)N3CCN(CC3)C(=O)N3CCN(C)CC3)c2c1)c1c(Cl)cncc1Cl

InChI Key InChIKey=HZRIHZUFAKGRMG-UHFFFAOYSA-N

Data  1 IC50  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 662581   

TargetFibroblast growth factor receptor 1(Human)
Tyra Biosciences

US Patent
LigandPNGBDBM662581(US20240109865, Example 4. | [4-[5-[5-[(1R)-1- (3,5...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2(Human)
Tyra Biosciences

US Patent
LigandPNGBDBM662581(US20240109865, Example 4. | [4-[5-[5-[(1R)-1- (3,5...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Tyra Biosciences

US Patent
LigandPNGBDBM662581(US20240109865, Example 4. | [4-[5-[5-[(1R)-1- (3,5...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3 [V555M](Human)
Tyra Biosciences

US Patent
LigandPNGBDBM662581(US20240109865, Example 4. | [4-[5-[5-[(1R)-1- (3,5...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
Tyra Biosciences

US Patent
LigandPNGBDBM662581(US20240109865, Example 4. | [4-[5-[5-[(1R)-1- (3,5...)
Affinity DataKd:  10nMAssay Description:Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and infected with T7 ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Tyra Biosciences, Inc.

Curated by ChEMBL
LigandPNGBDBM662581(US20240109865, Example 4. | [4-[5-[5-[(1R)-1- (3,5...)
Affinity DataIC50: 162nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed