BDBM662332 S)-N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(3- fluoro-4-(piperazin-1- yl)phenyl)azetidine-1- carboxamide::US20240109853, Compound A245::US20240226094, Compound A245

SMILES C[C@@](C#C)(c1csc(NC(=O)N2CC(C2)c2ccc(N3CCNCC3)c(F)c2)n1)c1ccc(Cl)cc1

InChI Key InChIKey=FRNQWCMLTKXOGB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 662332   

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662332(S)-N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol...)
Affinity DataIC50: 16nMAssay Description:In brief, dose-response studies were performed with HEK293 cells cultured in Dulbecco's Modified Eagle Medium (DMEM) supplemented 10% fetal bovine se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
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TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662332(S)-N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol...)
Affinity DataIC50: 16nMAssay Description:ALPK1 kinase activity was measured in an in vitro assay using ADP-Heptose as the ALPK1 ligand and activator of its kinase activity and TIFA protein a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent