BDBM662274 1-((2-(3- aminopyrrolidin-1- yl)pyrimidin-5- yl)methyl)-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A187::US20240226094, Compound A187

SMILES COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2cnc(nc2)N2CCC(N)C2)n1

InChI Key InChIKey=ALAAHADSWNOBDC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 662274   

TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662274(1-((2-(3- aminopyrrolidin-1- yl)pyrimidin-5- yl)me...)
Affinity DataIC50: 7nMAssay Description:In brief, dose-response studies were performed with HEK293 cells cultured in Dulbecco's Modified Eagle Medium (DMEM) supplemented 10% fetal bovine se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
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TargetAlpha-protein kinase 1(Human)
Shanghai Yao Yuan Biotechnology Co.

US Patent
LigandPNGBDBM662274(1-((2-(3- aminopyrrolidin-1- yl)pyrimidin-5- yl)me...)
Affinity DataIC50: 7nMAssay Description:ALPK1 kinase activity was measured in an in vitro assay using ADP-Heptose as the ALPK1 ligand and activator of its kinase activity and TIFA protein a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent