BDBM662042 2-chloro-N-(5-((E)-2-(2-(((1r,4r)-4- (dimethylamino)cyclohexyl)amino)pyrimidin- 5-yl)vinyl)-3-fluoro-6-methoxypyridin-2- yl)benzenesulfonamide::US11945784, Compound 50

SMILES COc1nc(NS(=O)(=O)c2ccccc2Cl)c(F)cc1\C=C\c1cnc(NC2CC[C@@H](CC2)N(C)C)nc1

InChI Key InChIKey=HVMXBXIREJSOOS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 662042   

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Cornell University

US Patent
LigandPNGBDBM662042(2-chloro-N-(5-((E)-2-(2-(((1r,4r)-4- (dimethylamin...)
Affinity DataIC50: 1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
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Date in BDB:
6/17/2024
Entry Details
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