BDBM662037 N-(5-(2-(2-((1r,4r)-4- aminocyclohexyl)amino)pyrimidin-5- yl)vinyl)-6-ethylpyridin-2-yl)-2- chlorobenzenesulfonamide::US11945784, Compound 45

SMILES CCc1nc(NS(=O)(=O)c2ccccc2Cl)ccc1C=Cc1cnc(NC2CC[C@H](N)CC2)nc1

InChI Key InChIKey=UMCZYTZVQFGTEP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 662037   

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Cornell University

US Patent
LigandPNGBDBM662037(N-(5-(2-(2-((1r,4r)-4- aminocyclohexyl)amino)pyrim...)
Affinity DataIC50: 1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
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Date in BDB:
6/17/2024
Entry Details
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