BDBM662014 2-chloro-N-(5-((E)-2-(2-(((1r,4r)-4- (dimethylamino)cyclohexyl) amino)pyrimidin-5-yl)vinyl)-3-fluoro-6- methylpyridin-2-yl)benzenesulfonamide::US11945784, Compound 22::US11945784, Compound 25

SMILES CN(C)[C@H]1CCC(CC1)Nc1ncc(\C=C\c2cc(F)c(NS(=O)(=O)c3ccccc3Cl)nc2C)cn1

InChI Key InChIKey=GHLVBGJOKKTDRZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 662014   

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Cornell University

US Patent
LigandPNGBDBM662014(2-chloro-N-(5-((E)-2-(2-(((1r,4r)-4- (dimethylamin...)
Affinity DataIC50: 1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Cornell University

US Patent
LigandPNGBDBM662014(2-chloro-N-(5-((E)-2-(2-(((1r,4r)-4- (dimethylamin...)
Affinity DataIC50: 1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2024
Entry Details
Go to US Patent