BDBM661994 N-(6-((E)-2-(2-(((1r,4r)-4- aminocyclohexyl)amino)pyrimidin-5- yl)vinyl)pyridazin-3-yl)-2- chlorobenzenesulfonamide::US11945784, Compound 2::US11945784, Compound 7

SMILES N[C@H]1CCC(CC1)Nc1ncc(\C=C\c2ccc(NS(=O)(=O)c3ccccc3Cl)nn2)cn1

InChI Key InChIKey=UGHPJTNIOJQQOH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 661994   

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Cornell University

US Patent
LigandPNGBDBM661994(US11945784, Compound 2 | N-(6-((E)-2-(2-(((1r,4r)-...)
Affinity DataIC50: 1nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
Cornell University

US Patent
LigandPNGBDBM661994(US11945784, Compound 2 | N-(6-((E)-2-(2-(((1r,4r)-...)
Affinity DataIC50: 3nMAssay Description:In vitro FRET assay was performed to evaluate the ability of select compounds to inhibit IRE1, the results of which are summarized in Table 3. To per...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2024
Entry Details
Go to US Patent