BDBM661933 (1R,2S,3R,5R)-3- {4-amino-5-bromo- 7H-pyrrolo[2,3- d]pyrimidin-7-yl}-5- [2-({6- azaspiro[3.4]octan-::US20240101589, Example 32

SMILES Nc1ncnc2n(cc(Br)c12)[C@@H]1C[C@@H]([C@@H](O)[C@H]1O)c1ccc2cc(CN3CCC4(CCC4)C3)[nH]c2c1

InChI Key InChIKey=ZHPWKXXHQQEEIH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 661933   

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM661933((1R,2S,3R,5R)-3- {4-amino-5-bromo- 7H-pyrrolo[2,3-...)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of full-length His-tagged METTL3/full length FLAG-tagged METTL14 (unknown origin) expressed in baculovirus expression system using synthet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
LigandPNGBDBM661933((1R,2S,3R,5R)-3- {4-amino-5-bromo- 7H-pyrrolo[2,3-...)
Affinity DataIC50: 6.10nMAssay Description:The enzymatic assay was established to determine IC50 values for inhibition of RNA methyltransferase activity. The enzyme used was full-length his-ta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2024
Entry Details
Go to US Patent