BDBM658053 6-[2,6-difluoro-3-(5-fluoro-2-methylpyridine-3-sulfonamido)phenyl]-N-methylimidazo[1,5-a]pyridine-1-carboxamide ::US20240083897, Compound 6

SMILES CNC(=O)c1ncn2cc(ccc12)-c1c(F)ccc(NS(=O)(=O)c2cc(F)cnc2C)c1F

InChI Key InChIKey=XZDFGGGCYBDMFZ-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 658053   

TargeteIF-2-alpha kinase GCN2(Human)
Hibercell

US Patent
LigandPNGBDBM658053(US20240083897, Compound 6 | 6-[2,6-difluoro-3-(5-f...)
Affinity DataIC50: 50nMAssay Description:GCN2 protein was obtained from Carna Biosciences (cat #05-153). The protein was diluted in assay buffer (ThermoFisher Scientific, #PV6135), 2 mM dith...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
Go to US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Hibercell

US Patent
LigandPNGBDBM658053(US20240083897, Compound 6 | 6-[2,6-difluoro-3-(5-f...)
Affinity DataIC50: 39nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Hibercell

US Patent
LigandPNGBDBM658053(US20240083897, Compound 6 | 6-[2,6-difluoro-3-(5-f...)
Affinity DataEC50:  460nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM658053(US20240083897, Compound 6 | 6-[2,6-difluoro-3-(5-f...)
Affinity DataEC50:  5.80E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed