BDBM658051 2-[3-(5-Chloro-2-methoxypyridine-3-sulfonamido)-2,6-difluorophenyl]-N-methylimidazo[1,5-b]pyridazine-5-carboxamide ::US20240083897, Compound 4

SMILES CNC(=O)c1ncn2nc(ccc12)-c1c(F)ccc(NS(=O)(=O)c2cc(Cl)cnc2OC)c1F

InChI Key InChIKey=DEMIJBHEBVXGEO-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 658051   

TargeteIF-2-alpha kinase GCN2(Human)
Hibercell

US Patent
LigandPNGBDBM658051(US20240083897, Compound 4 | 2-[3-(5-Chloro-2-metho...)
Affinity DataIC50: 50nMAssay Description:GCN2 protein was obtained from Carna Biosciences (cat #05-153). The protein was diluted in assay buffer (ThermoFisher Scientific, #PV6135), 2 mM dith...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
Go to US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Hibercell

US Patent
LigandPNGBDBM658051(US20240083897, Compound 4 | 2-[3-(5-Chloro-2-metho...)
Affinity DataIC50: 14nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargeteIF-2-alpha kinase GCN2(Human)
Hibercell

US Patent
LigandPNGBDBM658051(US20240083897, Compound 4 | 2-[3-(5-Chloro-2-metho...)
Affinity DataEC50:  110nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM658051(US20240083897, Compound 4 | 2-[3-(5-Chloro-2-metho...)
Affinity DataEC50:  870nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed