BDBM6569 6-(2,6-dichlorophenyl)-2-[(4-fluorophenyl)amino]-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one::PD173956

SMILES Cn1c2nc(Nc3ccc(F)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O

InChI Key InChIKey=ZSHRAUSJZQDIJR-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 6569   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6569(6-(2,6-dichlorophenyl)-2-[(4-fluorophenyl)amino]-8...)
Affinity DataIC50: 66.3nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6569(6-(2,6-dichlorophenyl)-2-[(4-fluorophenyl)amino]-8...)
Affinity DataIC50: 933nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2005
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6569(6-(2,6-dichlorophenyl)-2-[(4-fluorophenyl)amino]-8...)
Affinity DataIC50: 1.25E+3nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2005
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6569(6-(2,6-dichlorophenyl)-2-[(4-fluorophenyl)amino]-8...)
Affinity DataIC50: 5nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6569(6-(2,6-dichlorophenyl)-2-[(4-fluorophenyl)amino]-8...)
Affinity DataIC50: 380nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2005
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6569(6-(2,6-dichlorophenyl)-2-[(4-fluorophenyl)amino]-8...)
Affinity DataIC50: 921nMAssay Description:Inhibition of human recombinant SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM6569(6-(2,6-dichlorophenyl)-2-[(4-fluorophenyl)amino]-8...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant P38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM6569(6-(2,6-dichlorophenyl)-2-[(4-fluorophenyl)amino]-8...)
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM6569(6-(2,6-dichlorophenyl)-2-[(4-fluorophenyl)amino]-8...)
Affinity DataIC50: 290nMAssay Description:Inhibition of human recombinant C-KitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed