BDBM655473 US11912703, Example 455

SMILES CCCN1CCN([C@H](C)C1)c1ncc2[nH]c(c(C(C)C)c2c1F)-c1cn2ncnc2c(C)c1C

InChI Key InChIKey=XXCZTOXTSCMJMW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 655473   

TargetToll-like receptor 7(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM655473(US11912703, Example 455)
Affinity DataIC50: 0.590nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
Go to US Patent

TargetToll-like receptor 8(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM655473(US11912703, Example 455)
Affinity DataIC50: 0.170nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
Go to US Patent

TargetToll-like receptor 9(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM655473(US11912703, Example 455)
Affinity DataIC50: 1.46E+4nMAssay Description:HEK-Blue-cells (Invivogen) overexpressing human TLR7, TLR8 or TLR9 receptors were used for screening inhibitors of these receptors using an inducible...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
Go to US Patent