BDBM653429 4-(2,4-difluorophenyl)- 7-(4-methyl-1,3-thiazol- 5-yl)~2-(2-(2- propenoyl)-2,6- diazaspiro[3.4]octan-6- yl)-5,6,7,8-tetrahydro- 1,7-naphthyridine-3~ carbonitrile::US20240059703, Example 21-3

SMILES Cc1ncsc1N1CCc2c(C1)nc(N1CCC3(CN(C3)C(=O)C=C)C1)c(C#N)c2-c1ccc(F)cc1F

InChI Key InChIKey=PEOCMSYIAMBRDW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 653429   

LigandPNGBDBM653429(US20240059703, Example 21-3 | 4-(2,4-difluoropheny...)
Affinity DataIC50: 25nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
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Date in BDB:
4/24/2024
Entry Details
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