BDBM653336 (M)-1-(6-(4-(5-chloro- 1,6-dimethyl-1H- indazol-7-yl)-3-fluoro-7- (3-oxetanyl)-5,6,7,8- tetrahydro-1,7- naphthyridin-2-yl)-2,6- diazaspiro[3.4]octan-2- yl)-2-propen-1-one (2nd eluting isomer)::US20240059703, Example 14-107

SMILES Cc1c(Cl)cc2cnn(C)c2c1-c1c(F)c(nc2CN(CCc12)C1COC1)N1CCC2(CN(C2)C(=O)C=C)C1

InChI Key InChIKey=RJDZMNRDWVLOIS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 653336   

LigandPNGBDBM653336(US20240059703, Example 14-107 | (M)-1-(6-(4-(5-chl...)
Affinity DataIC50: 13nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
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Date in BDB:
4/24/2024
Entry Details
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