BDBM653220 4-(5-chloro-1H-indazol-4- yl)-7,7-dimethyl-2-(2-(2- propenoyl)-2,6- diazaspiro[3.4]octan-6-yl)- 7,8-dihydro-5H-pyrano[4,3- b]pyridine-3-carbonitrile::US20240059703, Example 13-148

SMILES CC1(C)Cc2nc(N3CCC4(CN(C4)C(=O)C=C)C3)c(C#N)c(c2CO1)-c1c(Cl)ccc2[nH]ncc12

InChI Key InChIKey=RFVWZINCJMYNKJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 653220   

LigandPNGBDBM653220(US20240059703, Example 13-148 | 4-(5-chloro-1H-ind...)
Affinity DataIC50: 26nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
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Date in BDB:
4/24/2024
Entry Details
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