BDBM653165 (6R,8R)-2-(2-acryloyl-2,6- diazaspiro[3.4]octan-6-yl)- 7,7-dimethyl-4-(5-methyl- 1H-indazol-4-yl)-5,6,7,8- tetrahydro-6,8- methanoquinoline-3- carbonitrile::US20240059703, Example 13-114::US20240059703, Example 13-115::US20240059703, Example 13-93

SMILES Cc1ccc2[nH]ncc2c1-c1c2C[C@H]3C[C@@H](c2nc(N2CCC4(CN(C4)C(=O)C=C)C2)c1C#N)C3(C)C

InChI Key InChIKey=HLIKIBRBOONGER-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 653165   

LigandPNGBDBM653165(US20240059703, Example 13-114 | (6R,8R)-2-(2-acryl...)
Affinity DataIC50: 53nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
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Date in BDB:
4/24/2024
Entry Details
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LigandPNGBDBM653165(US20240059703, Example 13-114 | (6R,8R)-2-(2-acryl...)
Affinity DataIC50: 1.38E+3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

LigandPNGBDBM653165(US20240059703, Example 13-114 | (6R,8R)-2-(2-acryl...)
Affinity DataIC50: 12nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent