BDBM653113 4-(3-hydroxy-1- naphthalenyl)-7,7-dimethyl- 2-(2-(2-propenoyl)-2,6- diazaspiro[3.4]octan-6-yl)- 7,8-dihydro-5H-pyrano[4,3- b]pyridine-3-carbonitrile::US20240059703, Example 13-41::US20240059703, Example 13-42::US20240059703, Example 13-43

SMILES CC1(C)Cc2nc(N3CCC4(CN(C4)C(=O)C=C)C3)c(C#N)c(c2CO1)-c1cc(O)cc2ccccc12

InChI Key InChIKey=LVOLUZDANAQOQH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 653113   

LigandPNGBDBM653113(US20240059703, Example 13-41 | 4-(3-hydroxy-1- nap...)
Affinity DataIC50: 33nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
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LigandPNGBDBM653113(US20240059703, Example 13-41 | 4-(3-hydroxy-1- nap...)
Affinity DataIC50: 2.33E+4nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
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LigandPNGBDBM653113(US20240059703, Example 13-41 | 4-(3-hydroxy-1- nap...)
Affinity DataIC50: 16nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent