BDBM653092 (7R)-4-(2-chlorophenyl)-7- (1-methyl-1H-pyrazol-5- yl)-2-(2-(2-propenoyl)-2,6- diazaspiro[3.4]octan-6-yl)- 5,6,7,8-tetrahydro-3- quinolinecarbonitrile. (1st eluting peak)::US20240059703, Example 13-20

SMILES Cn1nccc1[C@@H]1CCc2c(C1)nc(N1CCC3(CN(C3)C(=O)C=C)C1)c(C#N)c2-c1ccccc1Cl

InChI Key InChIKey=QXQTXHMLGFJXJJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 653092   

LigandPNGBDBM653092(US20240059703, Example 13-20 | (7R)-4-(2-chlorophe...)
Affinity DataIC50: 12nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
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Date in BDB:
4/24/2024
Entry Details
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