BDBM653030 1-(6-(4-(3-chloro-5- hydroxy-2- methylphenyl)-3,7,7- trimethyl-7,8-dihydro- 5H-pyrano[4,3- b]pyridin-2-yl)-2,6- diazaspiro[3.4]octan-2- yl)prop-2-en-1-one::US20240059703, Example 12-2::US20240059703, Example 12-43::US20240059703, Example 12-44

SMILES Cc1c(Cl)cc(O)cc1-c1c(C)c(nc2CC(C)(C)OCc12)N1CCC2(CN(C2)C(=O)C=C)C1

InChI Key InChIKey=FSUVQWABYIEDAW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 653030   

LigandPNGBDBM653030(1-(6-(4-(3-chloro-5- hydroxy-2- methylphenyl)-3,7,...)
Affinity DataIC50: 41nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

LigandPNGBDBM653030(1-(6-(4-(3-chloro-5- hydroxy-2- methylphenyl)-3,7,...)
Affinity DataIC50: 26nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

LigandPNGBDBM653030(1-(6-(4-(3-chloro-5- hydroxy-2- methylphenyl)-3,7,...)
Affinity DataIC50: 1.10E+4nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent