BDBM652918 (P)-1-(6-(3,7,7- trimethyl-4-(5- methyl-1H- indazol-4-yl)- 5,6,7,8- tetrahydro-2- quinolinyl)-2,6- diazaspiro[3.4] octan-2-yl)-2- propen-1-one (2nd eluting peak)::US20240059703, Example 2-11::US20240059703, Example 2-12::US20240059703, Example 2-28

SMILES Cc1ccc2[nH]ncc2c1-c1c(C)c(nc2CC(C)(C)CCc12)N1CCC2(CN(C2)C(=O)C=C)C1

InChI Key InChIKey=AENYBOOFAHBIET-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 652918   

LigandPNGBDBM652918(US20240059703, Example 2-12 | (P)-1-(6-(3,7,7- tri...)
Affinity DataIC50: 27nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

LigandPNGBDBM652918(US20240059703, Example 2-12 | (P)-1-(6-(3,7,7- tri...)
Affinity DataIC50: 1.11E+3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

LigandPNGBDBM652918(US20240059703, Example 2-12 | (P)-1-(6-(3,7,7- tri...)
Affinity DataIC50: 67nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent