BDBM652684 4-{[(4-{[(1-aminoisoquinolin-5-yl)amino]methyl}pyridin-2-yl)oxy]methyl}-1- methylpyridin-2-one::US20240059691, Example 4301

SMILES Cn1ccc(COc2cc(CNc3cccc4c(N)nccc34)ccn2)cc1=O

InChI Key InChIKey=MBFJFSDXDXLAQN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652684   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652684(US20240059691, Example 4301 | 4-{[(4-{[(1-aminoiso...)
Affinity DataIC50: 650nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
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TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652684(US20240059691, Example 4301 | 4-{[(4-{[(1-aminoiso...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent