BDBM652682 5-N-({2-[(1-isopropylpiperidin-4-yl)methoxy]pyridin-4-yl}methyl)isoquinoline-1,5- diamine::US20240059691, Example 4299

SMILES CC(C)N1CCC(COc2cc(CNc3cccc4c(N)nccc34)ccn2)CC1

InChI Key InChIKey=AIRGERSZASMAFK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652682   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652682(US20240059691, Example 4299 | 5-N-({2-[(1-isopropy...)
Affinity DataIC50: 200nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652682(US20240059691, Example 4299 | 5-N-({2-[(1-isopropy...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent