BDBM652424 3-chloro-N-(4-((1-methylpiperidin-4-yl)oxy)benzyl)-1H-pyrrolo[2,3-b]pyridin-5-amine::US20240059691, Example 1004

SMILES CN1CCC(CC1)Oc1ccc(CNc2cnc3[nH]cc(Cl)c3c2)cc1

InChI Key InChIKey=ITXMGHQYSZOAPX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652424   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652424(US20240059691, Example 1004 | 3-chloro-N-(4-((1-me...)
Affinity DataIC50: 2.50E+4nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
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TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652424(US20240059691, Example 1004 | 3-chloro-N-(4-((1-me...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent