BDBM652298 US20240059675, Example 2::US20240101544, Example 133

SMILES Cn1cnnc1C1CCN(CC1)c1c(ccnc1-c1ccc(F)nc1)C#N

InChI Key InChIKey=NERICNILRRVFEJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 652298   

TargetGlutaminyl-peptide cyclotransferase-like protein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM652298(US20240059675, Example 2 | US20240101544, Example ...)
Affinity DataIC50: 2nMAssay Description:QPCT or QPCTL dependent conversion of N-terminal glutamine to pyroglutamate of CD47 was monitored via MALDI-TOF MS. Test compounds were dissolved in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

TargetGlutaminyl-peptide cyclotransferase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM652298(US20240059675, Example 2 | US20240101544, Example ...)
Affinity DataIC50: 17nMAssay Description:QPCT or QPCTL dependent conversion of N-terminal glutamine to pyroglutamate of CD47 was monitored via MALDI-TOF MS. Test compounds were dissolved in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
Go to US Patent

TargetGlutaminyl-peptide cyclotransferase-like protein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM652298(US20240059675, Example 2 | US20240101544, Example ...)
Affinity DataIC50: 100nMAssay Description:Compound IC50 values for the inhibition of QPCTL activity were determined using a biochemical fluorescent-based assay. QPCTL activity was measured in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
Go to US Patent

TargetGlutaminyl-peptide cyclotransferase(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM652298(US20240059675, Example 2 | US20240101544, Example ...)
Affinity DataIC50: 100nMAssay Description:Compound IC50 values for the inhibition of QPCT (rhQPCT, R&D Systems) activity were determined using a biochemical fluorescent-based assay. QPCT acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
Go to US Patent